iosBio appoints Patricia Londono-Hayes as Chief

Oral vaccines and biotherapeutics company strengthens senior leadership team with new role to drive priority development programmes Burgess Hill, UK, 14 June 2021—iosBio (‘the Company’), a UK-based biotechnology company developing next-generation vaccines that can be administered orally, today announces the appointment of Patricia Londono-Hayes, PhD, as Chief Development Officer.

With more than 20 years of experience in the pharmaceutical and biotechnology sector, Patricia is a leader in vaccines and biologics product development. She brings extensive experience in the progression of vaccine candidates from initial concept into first-in-human testing, advancement of clinical development and licensing.

In her role, Patricia will lead the development and execution of iosBio’s pipeline strategy, as the Company moves into its next stage of growth. In January 2021 iosBio signed an exclusive worldwide licensing agreement granting ImmunityBio rights to its OraPro™ vaccine platform technology for the oral delivery of ImmunityBio’s second-generation human Adeno (hAd5) COVID-19 vaccine candidate. iosBio’s second priority programme, OraPro-Flu – a thermally stable, orally-delivered, quadrivalent seasonal influenza vaccine – is currently in preclinical studies and expected to enter the clinic later this year.

Across her career, Patricia has directed global programmes, teams, and partnerships at scientific, strategic, and operational levels, contributing to the development and licensing of vaccines spanning a broad range of indications including influenza and a variety of respiratory, gastro-intestinal, genitourinary, and nosocomial infections.

Patricia joins iosBio from Sanofi Pasteur, where she held positions of increasing responsibility, most recently as Head of External R&D Initiatives and Scientific Affairs, Europe, where she led the strategy and implementation of external R&D public‐private partnerships and alliances. During her tenure, she spearheaded multi million Euro investments in R&D partnerships between the company and other vaccine manufacturers, leading academic institutions, the EU and the Gates Foundation. Prior to that, she was Head of Global Preclinical Research & Development Department and Leader of the Universal Influenza Vaccine Project at the company, overseeing, translational, preclinical, and clinical pharmacology research. Before joining Sanofi Pasteur, Patricia worked at vaccine company Acambis, where she founded and directed the Immunology Research Department and initiated research programs in oral vaccines.

She gained her PhD in Biochemistry and Immunology from Imperial College London and holds an MSc in Molecular Biology and Genetic Manipulation and a BSc in Microbiology from the University of Sussex and University of Los Andes, respectively.

Executive Chairman of iosBio, Wayne Channon said: “With her impressive track record in vaccine development, I am delighted to welcome Patricia to iosBio. Her breadth of experience in leading vaccines programmes from idea through to clinical development will be critical as we pursue our mission to lead the way in next generation, oral vaccines.”

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Patricia Londono-Hayes commented: “I am thrilled to be joining iosBio at such an exciting stage, with the Company’s OraPro™ vaccine platform technology being investigated in trials of what could be the first oral COVID-19 vaccine. iosBio’s science has the potential to truly transform vaccine development and to overcome the global challenges of traditional vaccines. I am delighted to be joining such an experienced and innovative team and look forward to working together on IosBio’s vision to bring orally administered, thermally stable vaccines to people around the world.”

Ends

For further information please contact:

Consilium Strategic Communications

Mary-Jane Elliott, Melissa Gardiner, David Daley

IosBio@consilium-comms.com

Tel: +44 (0) 20 3709 5700

NOTES FOR EDITORS

About iosBio

iosBio is a UK based biotechnology company developing next generation vaccines that can be administered orally.

The Company’s proprietary OraPro™ thermal stabilization technology enables the oral administration of thermally stable, non-replicating viral vectors that can be delivered sublingually via the gastrointestinal (GI) tract and other routes. These vaccine vectors are engineered to withstand temperatures of up to 50 degrees and the hostile conditions in the stomach without loss of efficacy and providing long term product stability at ambient temperatures. iosBio is developing vaccines designed to stimulate mucosal, systemic and T cell immune responses, providing robust immunity to a number of infectious diseases including COVID-19, Zika and influenza.

In January 2021 iosBio announced an exclusive worldwide licensing agreement with ImmunityBio, Inc. a US-based, privately held clinical-stage immunotherapy company, for iosBio’s OraPro™ vaccine platform technology currently being investigated in a Phase Ib trial of ImmunityBio’s secondgeneration human Adeno (hAd5) COVID-19 vaccine candidate.

iosBio is headquartered in Burgess Hill, UK. For more information visit: iosbio.com

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The team of doctors and scientists at iosBio believe that the next great leap forward in immunization will be oral delivery


Enabling the fastest and most cost-effective deployment of vaccines the world has ever seen. This is not just a huge leap forward from a humanitarian perspective, oral vaccine technology also represents a significant commercial opportunity.

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    As the coronavirus pandemic rages on around the world, scientists are working day and night to create safe and effective vaccines that will allow life to return to normal. Although great leaps forward have been made, we are already seeing the supply chain and logistical problems of injectable vaccines that require cold or ultra cold chain storage. And as further mutations of the virus continue to emerge, the ability to tweak and readminister vaccines becomes ever more crucial.

    iosBio has partnered with US pharmaceutical company ImmunityBio to create OraPro-Covid-19, deploying our ground-breaking oral vaccine delivery platform with the aim of creating a Covid-19 vaccine that can be sent by post and swallowed at home.

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    The global seasonal influenza market is forecast to be worth $4.3bn by 2025. This figure is unsurprising considering the enormous economic costs of flu each year.

    On average, the total estimated annual economic burden of influenza to the US healthcare system and society is $11.2 billion, comprising $3.2 billion in direct medical costs and $8 billion in indirect costs. The CDC (Centre for Disease Control and Prevention) recommends that every person from the age of six months onwards has a flu vaccine, but actual vaccination coverage hovers around 50%

    In the UK, six million working days are lost to seasonal influenza in an average winter, yet uptake amongst the under-65s has been steadily declining in recent years. Many cite difficulties with getting an appointment at their GP’s surgery, where the vast majority of flu jabs are still administered.

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    Zika virus disease is caused by a virus transmitted primarily by mosquitoes, as well as through sexual contact and from mother to fetus during pregnancy. Zika infection during pregnancy can cause infants to be born with microcephaly and other congenital malformations, and is also associated with other complications including preterm birth and miscarriage. An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including Guillain-Barré syndrome, neuropathy and myelitis.

    From the 1960s to 1980s, rare sporadic cases of human infections were found across Africa and Asia, typically accompanied by mild illness. The first recorded outbreak of Zika virus disease was reported from the Island of Yap in Micronesia in 2007. This was followed by a large outbreak of Zika virus infection in French Polynesia in 2013 and other countries and territories in the Pacific. In March 2015, Brazil reported a large outbreak of rash illness, soon identified as Zika virus infection, and later that year confirmed to be associated with microcephaly and Guillain-Barré syndrome.

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